As for interleukin 33, in their study, Yin et al. constructed a recombinant replication-deficient adenovirus encoding soluble ST2-human immunoglobulin (Ig) G1 Fc (sST2-Fc), and studied its beneficial effect in a murine model of ovalbumin (OVA)-sensitized asthma, reporting that the protective effect of sST2-Fc in allergic lung inflammation is related to blocking IL-33/ST2L signaling. Here, IL1RL1 is linked to asthma.