ROS levels are related to aging and metabolic dysregulation [61] as Resf1 down expression, along with biomarkers of hepatic inflammation (Saa1/2 and Lcn2) that are significantly correlated with hepatic triglycerides, offers a vision of how the absence of Txndc5 has an impact on hepatic steatosis as a global multifactorial disease in which more studies need to be addressed. This evidence concerns the gene TXNDC5 and fatty liver disease.