At the same time, the protein kinase R-like ER kinase (PERK)/CHOP signaling pathway can motivate cell apoptosis; phosphorylated eukaryotic initiation factor 2α (p-eIF2α) can weaken tumor invasion; the deletion of Beclin-1 can result in the initiation of a tumor [62,63]. This evidence concerns the gene EIF2AK3 and neoplasm.