For example, the 78 kDa glucose-regulated protein/binding immunoglobulin protein (GRP78/BiP) can promote tumor cell survival and metastasis through the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway; spliced X-box binding protein 1 (XBP1s) (a transcription factor) can facilitate angiogenesis; activating transcription factor 6 (ATF6) can induce drug resistance. The gene discussed is HSPA5; the disease is neoplasm.