Shushu Song found that compared to normal hepatocytes, RTN3 is poorly expressed in HCC and acts as a tumor suppressor by driving growth arrest in vitro and in vivo by facilitating p53 Ser392 phosphorylation through Checkpoint kinase 2 (Chk2); however, the role of RTN3 in cancers still requires adequate experimentations [40]. This evidence concerns the gene RTN3 and hepatocellular carcinoma.