Earlier studies established that a soluble form of recombinant human ACE-2 (rhACE-2; APN01 (0.4 mg/kg, IV, BID for 7 days), GSK2586881: 0.4 mg/kg, IV, BID for 3 days) neutralized excessive SARS-CoV virus and enhanced the protective cellular action of ACE-2 in ARDS patients [88,89]. Here, ACE2 is linked to acute respiratory distress syndrome.