In patients at risk of NAFLD, several multivariate tests used at least one of these three proteins for the non-invasive diagnosis or prognosis of liver features [73,74], as follows: A2M (FibroTest/FibroSure [35,37,75], FibroMeter V2G and V3G [73,74], Hepascore [73,74], and NIS4 [76]), ApoA1 (FibroTest/FibroSure, Chunming score, Shukla score) [35,37,77,78], and haptoglobin (FibroTest/FibroSure Fuc–Hpt–Mac2bp) [35,37,79]. The gene discussed is MRS2; the disease is metabolic dysfunction-associated steatotic liver disease.