Several recent studies separating the roles of the main HDL components, such as HDL2, HDL3, and ApoA1 (or according to the HDL size), have suggested that the causal relationships between serum levels of ApoA1 with clinical endpoints such as cardiovascular events [13], risk of severe COVID-19 [14], or glycosylated hemoglobin [96] were easier to prove than using the HDL overall levels. The gene discussed is JPH3; the disease is COVID-19.