In such correlations, the mechanisms explaining the variability of serum haptoglobin could be both genetic defects (such as Gata6 gene and a decrease in zonulin—the pre-haptoglobin protein), and specific environmental factors (such as high-fat diet, alcohol, fiber-deprived diet, bacterial or viral infection, and medication exposure) known to contribute to break the intestinal barrier balance and promote gut dysbiosis [102]. Here, GATA6 is linked to viral infectious disease.