A2M and type 2 diabetes mellitus: This is in line not only with the role of A2M as a regulator of the extracellular matrix [19,23,26] and the well-known positive association of A2M in the extracellular matrix of liver fibrosis (Supplementary Table S1) [19,23,30,32,33,34,35,36,37,38], but also with the early damage of proteins associated with the very early presence of T2DM [19,27,28,29,80].