In the RNU cohort, the median preoperative serum MMP-7 level of 10.6 ng/mL significantly decreased to 6 ng/mL (p < 0.001), suggesting that MMP-7 levels are directly associated with the presence of UTUC (Figure 3A,D). The gene discussed is MMP7; the disease is renal pelvis/ureter urothelial carcinoma.