CD4 and mitochondrial DNA depletion syndrome 4a: A Tg mouse model for HLA-B*57:01-linked ABC drug tolerance and reactivity by Cardone et al. in 2018 revealed the necessity of enhanced DC maturation and APC co-stimulation through the depletion of CD4+ cells to provoke ABC-reactive CD8+ T cells with the potential to cause AHS in the respective mice [29].