In one study conducted at 150 sites in the US and Mexico that included 1191 men with PCa undergoing GnRH agonist treatment and 59 subjected to bilateral orchidectomy, the mean serum levels of LH (range) were 1 UI/L (1–526) and 159 UI/L (33–369), respectively [12]. The gene discussed is GNRH1; the disease is posterior cortical atrophy.