KLK3 and posterior cortical atrophy: The current specific criteria to define the progression of PCa after castration are those proposed by the PCWG 2, in which biochemical progression is defined as an over 25% increase in serum prostate-specific antigen (PSA) within two consecutive measurements separated by at least one week, with a 2.0 ng/mL minimum increase over the starting value, and PSA doubling time is also incorporated to predict the aggressiveness of progression [10].