The 14-3-3 positivity was much higher in the comorbidity subgroups (CJD/tau 67 out of 110, 60.91%; CJD/AD 24 out of 33, 72.73%; CJD/FTLD 6 out of 7, 85.71%; and CJD/others 2 out of 3; 66.67%). This evidence concerns the gene MAPT and Alzheimer disease.