PRNP and neurodegenerative disease: Sixth, from the genetic point of view, we found no differences between codon 129 status of the PRNP gene or between genetic and sporadic CJD; in line with our pilot study, no prominent abnormalities in the deep genetic analysis of “pure” CJD cases and CJD cases in comorbidity with AD and tauopathies, respectively were seen, nor in the analysis of 15 genes related to the most important neurodegenerative diseases [30].