AKT1 and acute myeloid leukemia: Furthermore, it has been shown that CD157 signaling activates the SRC-family protein, tyrosine kinase, phosphoinositide 3-kinases (PI3Ks)/protein kinase B/Akt, mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) pathways and, thus, increased survival of acute myeloid leukemia cells [16].