CASP1 and male reproductive organ cancer: Wang et al. demonstrated that LESW significantly suppressed the expression of IL-1β, COX-2, caspase-1, and NGF on day 3, and IL-1β, TNF-α, COX-2, NALP1, caspase-1, and NGF expression on day 7, in a dose-dependent fashion in a capsaicin-induced prostatitis model in rats [75].