Enhanced level of mRNA coding the IL6, IL10, IL12, sICAM-1, sICAM-3, sPECAM-1, and CD40L proteins, whose secretion by the keratinocytes was inhibited by EVs (Figure 7b,d,e,g–i,o), correlated with the better survival prognosis of the patients with metastatic melanoma (Figure 8a,c–e,g–i,o). The gene discussed is IL6; the disease is metastatic melanoma.