Moreover, the upregulation of IL10 with the concomitant downregulation of IL12 is characteristic for the immunosuppressive microenvironment [82]; thus, the upregulation of IL10 with the significant downregulation of the IL12 secretion by the keratinocytes may indicate that “acidic” EVs drive the formation of the immunosuppressive microenvironment during the melanoma progression. This evidence concerns the gene IL10 and melanoma.