It was revealed that the incubation with “normal” EVs led to the significant decrease in secretion of the IL6, IL8, and IL10 immunomodulatory cytokines and different cell adhesion regulators, which are also capable of attracting the immunocompetent cells to the tumor lesion: sICAM-1, sICAM-3, sPECAM-1, sE and sP-selectins, t-PA, and sCD40L (Figure 7b–d,g–i,k,l,n,o). Here, IL6 is linked to neoplasm.