IL6 activates the antitumor immunity [85], regulates the secretion of the anti-inflammatory cytokine IL10 [86] in the melanoma cells via the PI3K and ERK related pathways [87], and promotes the E/P-selectin- and ICAM-1-dependent extravasation of the cytotoxic T cells in melanoma lesions in vivo [88]. The gene discussed is SELP; the disease is melanoma.