CD40LG and metastatic melanoma: Enhanced level of mRNA coding the IL6, IL10, IL12, sICAM-1, sICAM-3, sPECAM-1, and CD40L proteins, whose secretion by the keratinocytes was inhibited by EVs (Figure 7b,d,e,g–i,o), correlated with the better survival prognosis of the patients with metastatic melanoma (Figure 8a,c–e,g–i,o).