Melanoma EVs also accelerate the migration of melanoma cells to the lung and lymph nodes by activation of the calgranulin A/serum amyloid A/Toll-like receptor4/NFκB signaling cascade and expression of tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF), and hypoxia-inducible factor 1 (HIF-1) [22,23,24]. Here, NFKB1 is linked to melanoma.