Here, we showed that EVs from the metastatic melanoma cells inhibit the release by keratinocytes of the IL6, IL8, IL10, and IL12 immunomodulatory cytokines and the regulators of cell adhesion and immune cell infiltration, such as sICAM-1, s-ICAM-3, sPECAM-1, sE- and sP-selectins, t-PA, and sCD40L (Figure 7). Here, IL10 is linked to melanoma.