AOPEP and coronary artery disorder: At the same time, a large meta-analysis of 40 studies involving 11,396 patients and 46,938 controls concluded that individuals with smaller apo(a) isoforms have a higher relative risk (RR) of developing coronary heart disease (CHD) (RR = 2.08, 95% CI: 1.67 to 2.58) compared to individuals with larger apo(a) isoforms (intending 22 or fewer KIV type 2 repeats versus >22 repeats, or analogously an apo(a) molecular weight of <640 kDa versus ≥640 kDa) [32].