IGFBP1 and neoplasm: This cluster reduces tumor growth by inhibiting proteins involved in important cellular processes, including homeobox A1 (HOXA1), mammalian target of rapamycin (mTOR), insulin-like growth factor binding protein 1 (IGFBP1), and fibroblast growth factor receptor 3 (FGFR3) [52,53,54,55].