Human PBGD (hPBGD) mRNA administration in AIP mice rescued the hepatic PBGD activity over the course of the acute attack (~7–10 days) and its stability in hepatic parenchyma was enhanced when PBGD mRNA was conjugated with liver-targeted apolipoprotein A1 (ApoA1), a structural part of high-density lipoprotein (HDL) [15,99,100]. The gene discussed is APOA1; the disease is autoimmune pancreatitis.