The major steps forward for the treatment of AIP were carried out in recent years with (1) the approval of givosiran (Alnylam Pharmaceuticals, Inc., Cambridge, MA, USA), which inhibits ALAS1 through RNA interference (RNAi) in patients aged at least 12 years, and (2) with the ongoing efforts in the development of therapies based on the replacement of nonfunctional PBGD with hepatic delivery of the mRNA or protein [11,12,13,14,15]. This evidence concerns the gene ALAS1 and autoimmune pancreatitis.