Interestingly, some patients with STXBP1 encephalopathy, later develop juvenile-onset parkinsonism, and changes to STXBP1 levels are seen in Alzheimer’s disease, together suggesting a connection between STXBP1 and neurodegenerative diseases with protein aggregates [64,65]. Here, STXBP1 is linked to early-onset autosomal dominant Alzheimer disease.