In the present study, we observed that a significant and positive correlation between the expression of KIFC1 and the infiltration of MDSCs was present in all of the tumor types, except for HNSC-HPV+ and THCA, while the expression of KIFC1 was negatively correlated with the ImmuneScore, which was used to quantify the in situ T-cell infiltration in most of the tumors in the TCGA database. Here, KIFC1 is linked to neoplasm.