As a correlation was found between the miR-let-7d and miR-26 and C3 and between miR-26 and IgG2 that can activate the classic complement system, it was tempting to speculate that the lower levels of miR-26 and miR-let-7d are an early event in the development of SSc-PAH, at the stage of autoimmune attack. Here, C3 is linked to pulmonary arterial hypertension.