FCGR3A and neoplasm: The lack of FcεRIγ that leads to exclusive coupling of CD16 to the TCRζ adaptor [18] has been mechanistically linked to the functional hyperresponsivity to receptor stimulation in vitro, a cardinal feature of memory identity [7,26]; FcεRIγ− memory NK cell in vitro proliferation induced by contact with virus-infected or tumour cells has been previously demonstrated to depend on the presence of opsonizing Abs [5,6,24].