Contrarily, the plasma levels of proteins involved in immune response (IL6, IL23, anti-factor VIII, and immunoglobulin GCT-A3) and signal transduction (POTE ankyrin domain family member F/POTEF, AT motif binding factor1/ATBF1, and trimethylguanosine synthase/TGS1) were higher in plasma of psoriasis patients. The gene discussed is TGS1; the disease is psoriasis.