This finding is consistent with clinical evidences that, besides recognizing a central role of IL-6 as a marker of COVID-19 severity [31,32,33], report increased levels of IL-8 in patients with COVID-19-related ARDS [16] and in severe COVID-19 patients [34]; moreover, high serum IL-8, together with IL-6 and TNFα, were associated with poor survival [35]. This evidence concerns the gene TNF and acute respiratory distress syndrome.