Similarly, the Janus Kinases (JAKs)/Signal Transducers and Activators of Transcription (STAT) axis is known to be deeply involved in the onset of cytokine storm in COVID-19 [45], and, accordingly, a significant increase of p-STAT3 (Tyr705)-positive pneumocytes and inflammatory cells have been detected in the lungs of affected patients [46]. Here, STAT3 is linked to COVID-19.