So, we focused on well-known genes involved in CLL pathogenesis, such as apoptosis related genes (namely DAPK1, BCL2L1, BCL2L2, XIAP, ABL1, BCL2, BAG3, BAD, BAX, AIFM1, HRK), NF-kB dependent genes (FOS, BIRC3, NFKB1), microenvironment related genes (CSF1, CD83, CD40, IGF1R) and inflammatory genes (IL8, CCL2, CXCL2, CASP5, IL10, IL1B, IL1A). The gene discussed is HRK; the disease is B-cell chronic lymphocytic leukemia.