As expected, no evidence of apoptosis was observed in both naïve and Tx-R HCC 1806 cells treated with FGFR inhibitor (Figure 6A,B, respectively), whereas PTX treatment resulted in a substantial increase of the cleaved PARP and caspase-3 in the naive, but not Tx-R HCC 1806 cells (Figure 6A,B, respectively), thereby revealing the resistance to PTX in Tx-R HCC 1806 subline. The gene discussed is CASP3; the disease is hepatocellular carcinoma.