Finally, ABCC1/MRP1 was found as an effective transporter of imatinib from chronic myeloid leukemia (CML) cells [63], whereas sorafenib was proposed as a substrate for ABCC2/MRP2 [64], therefore causing sorafenib resistance of renal carcinoma cell lines in vitro. The gene discussed is ABCC2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.