The importance of some of these candidates is worth mentioning: Cxcl1 was recently found to mediate the effects of KRAS-IKKα addiction during malignant pleural effusion development [16]; Casp3 is a central effector of compensatory tumor proliferation and radiotherapy resistance [35]; and Gmnn was recently found to function as a tumor suppressor in lung and colon cancer [36]. The gene discussed is CASP3; the disease is colonic neoplasm.