To replicate these results in vivo, we induced subcutaneous tumors in C57BL/6, FVB, and Rag2−/− (recombination activating gene 2) mice using six different cancer cell lines and initiated daily intraperitoneal saline or deltarasin (15 mg/Kg in saline) treatments after tumor establishment (tumor volume ≥ 100 mm3; latency ≥ 14 days post-sc injection). Here, RAG2 is linked to neoplasm.