MTOR and Angelman syndrome: Although mTOR activity has been related with the late long-term potentiation (L-LTP) that underlies LTM [38], some investigations have described controversial findings after the inhibition of the mTORC1 pathway, such as augmented learning and synaptic plasticity in the hippocampus of mice with Angelman syndrome [39], increased neurite outgrowth [40], or improved cognitive and affective deficits [41].