IFNG and neoplasm: Among speculative theories as to why ASPS may respond to CPIs is the possibility that the high degree of intratumoural vascularity confers greater concentrations and/or sensitivity to the chemokines that attract immune effectors to the tumour bed or that upregulation of pro-inflammatory cytokines such as IFNγ is among the transcriptional targets of the aberrant APSCR1-TFE3 transcription factor—such theories are yet to be substantiated by translational evidence [55,56,57].