HIF1A and prediabetes syndrome: On the other hand, the use of different protocols of adaptation to interval hypoxia in patients with prediabetes, MS, DM2T, and overweight leads to normalization of insulin production in OGTT, HIF-1α dependent enhancement of mRNA expression pyruvate dehydrogenase kinase PDK-1, increased glycolytic efficiency, and HOMA-IR scores [19,20,23,50].