The observed pre-intervention indices changes, such as the decreased liver fibrosis and steatosis degrees, and changes in the levels of TC, LDL, ALT, AST, as well as in CRP-hs and NTproBNP cardiac overload indicator were significantly more pronounced (p = 0.02 − 0.001) in the IHHE group. Here, NPPB is linked to Hepatic fibrosis.