A recent study assessed the therapeutic potential of IL-35 recombinant protein in a mouse model of colitis; the IL-35 treatment decreased the infiltration of macrophages, CD4+ T and CD8+ T cells and promoted the Treg cell infiltration, increased the IL-10 production and decreased IL-6, TNF-α, and IL-17A, alleviating the inflammation in acute colitis [95]. This evidence concerns the gene CD8A and colitis.