Molecular analyses revealed that oncolytic NDV (i) can use multiple ways of cell entry, (ii) can interfere with multiple cancer-typical signaling pathways, (iii) can use multiple branches of UPR signaling, (iv) can kill cancer cells in multiple ways, (v) can use multiple ways of breaking therapy resistance, (vi) can activate immune cells in multiple ways, and (vii) can activate multiple interferon regulatory factors (IRF-1,-3,-4,-7,-9). This evidence concerns the gene IRF1 and cancer.