The increased expression of TDO2 mRNA and protein in the frontal cortex (Brodmann’s area 10) and in the anterior cingulate cortex of individuals with psychosis [160,163] was complicated by the finding that Western blots of normal control tissue from two unrelated individuals, using the antibodies designed to respond to two different epitopes (termed “A” and “B”), each uniquely recognized different isoforms of shorter length (~32 kD and ~35 kD, respectively; Figure 6) than the expected 47 kD, full-length TDO2. The gene discussed is TDO2; the disease is psychotic disorder.