An initial genetic association study of TDO2 in psychosis determined that although a SNP in intron 4 (rs2271537) was not significantly associated with schizophrenia and bipolar disorder as a single locus, a complex genotype illustrated significant gene–gene interaction of a homozygous form of this SNP (CC) with 2 other loci, the melanotropin receptor MC5R, and the melanotropin receptor MCHR2 [65]. This evidence concerns the gene MC1R and bipolar disorder.