In particular, macrophage chemoattractant molecules [e.g., C-C Motif Chemokine Ligand 2 (CCL2)/monocyte chemoattractant protein 1 (MCP-1), colony-stimulating factor 1 (CSF-1)] play a major role to recruit TAMs into the tumor microenvironment. The gene discussed is CSF1; the disease is neoplasm.