ITGA3 and metabolic dysfunction-associated steatohepatitis: The I3PA treatment of LX-2 human hepatic stellate cells in vitro significantly reduces the mRNA gene expression of type I collagen (COL1A2), integrin subunit alpha 3 (ITGA3) and αSMA, which are required for the activation, cell migration and cell adhesion of LX-2 cells upon TGF-β1 stimulation, implying that I3PA has a potential function as an antifibrotic agent in NASH [127].