Nonetheless, patients with a high PD-L1 CPS (≥10) had considerable therapeutic benefit compared to those with paclitaxel (median OS 10.4 vs. 8.0 months, HR 0.64, 95% CI 0.41–1.02), indicating that the proportion of tumor cells that express PD-L1 may affect the ICI treatment response [13]. This evidence concerns the gene CD274 and neoplasm.