GPR55 activates the Gαq/12 and Gα13 G proteins and increases intracellular Ca2+, ERK phosphorylation, protein RhoA activation, and hippocampal release of glutamate, mediating procedural memory modulation, motor coordination, and anxiety-like behavior [180], and having a proinflammatory role in innate immunity [71]. The gene discussed is GPR55; the disease is Anxiety.