With regard to histopathological grade, SCTR staining was found highest in well-differentiated G1 ESCC and EAC, yet IHC score was only gradually lower in G2 and typically still high even in G3 tumors as compared to normal esophageal tissue (Figure 1 and Supplementary Figures S2 and S4). This evidence concerns the gene SCTR and esophageal squamous cell carcinoma.