VWF supports tumor metastasis via multiple postulated mechanisms, including promoting the tumor extravasation process by stimulating pro-inflammatory signaling and increasing vascular permeability, aiding tumor cell adhesion to endothelial cells and stimulating angiogenesis into the tumor microenvironment, as well as assisting with the carriage of tumor cells to distant sites [73,96]. The gene discussed is VWF; the disease is neoplasm.