The VWF antigen to ADAMTS13 activity ratio outperformed other tested biomarkers for HCC, such as alpha fetoprotein, VEGF, and des-y-carboxy prothrombin, was comparable to the multivariate biomarker of alpha-fetoprotein-L3%, and exclusively correlated with both the tumor volume and stage as well as plasma VWF levels [137]. Here, AFP is linked to neoplasm.