The role of VWF in mediating vascular permeability is shown in an intracranial model of a hemorrhage, where VWF infusion resulted in increased vascular permeability that was attenuated by anti-VWF antibodies [104], as well as a study demonstrating how a subendothelial VWF is inhibitory to claudin-5 expression, a tight junction protein expressed on endothelial cells [105]. The gene discussed is VWF; the disease is hemorrhage.