VWF and neoplasm: There are examples of colon carcinoma [92], gastric cancer [89] and lung adenocarcinoma [77] displaying high levels of VWF expression in the tumor stroma, which is thought to be mediated by either an increase in the tumor vasculature VWF gene expression [77] or due to the high density of exposed collagen and leaky vasculature in solid tumors, leading to an increased accumulation of VWF via binding to the collagen binding A3 domain of VWF [93].