VEGFA and neoplasm: The exact biological course of the synchronous and metachronous liver metastases is still unknown; however, a review of the literature confirms that they exhibit different biological characteristics to their respective CRC primary tumours [36,37], such as the reduction in p27 expression in the metachronous group, suggesting that there is a “posttranslational” degradation of the proteins in the liver metastases [32], or Kim et al. [32,38] finding a higher expression of VEGF within the synchronous metastases group than in the CRC primary tumour.