Although tramadol injection, aceclofenac, and diclofenac injection were most frequently used for musculoskeletal diseases, non-NSAIDs (e.g., acetaminophen and tramadol) and loxoprofen (a mixed COX-1/COX-2 inhibitor) constituted more than 50% of the overall analgesics prescribed for respiratory and other diseases. This evidence concerns the gene PTGS2 and musculoskeletal system disorder.