While nuclear chromatin-associated (n)PKC-θ is associated with breast cancer and other diseases, in healthy T cells, cytoplasmic PKC-θ selectively translocates to the immunological synapse during T-cell receptor (TCR)/CD28 co-stimulation [8,9,10,11,12], where it transiently phosphorylates and regulates transcription factors (e.g., NF-κB, AP-1, and NFAT) during T-cell activation [10,13,14]. The gene discussed is PRRT2; the disease is breast cancer.