ARHGEF4 and cancer: The docetaxel-inhibited gene group was enriched for IFNA response [57], cancer EMT signature [58], integrin 1 pathway, and collagen metabolic processes and included genes such as FN1, TNFSF10, IFIT3, IFI44, ARHGEF4/9, several collagen and serpin genes, and the transcription factors FOXS1, ZEB2, BHLHE41, RUNX2, and RORB (Figure 5E,F).