PRRT2 and cancer: Next, we identified direct gene targets of nPKC-θ from cancer-associated pathways using RNA samples isolated from MDA-MB-231 murine tumors treated with nPKC-θi2 using the NanoString pan-cancer panel and overlaying the results with chromatin immunoprecipitation (ChIP) sequencing data [6] from MDA-MB-231 enriched for PKC-θ (Figure 4C).