Cytotoxicity assays based on tetrazolium dye reduction (WST-8) revealed a comparable efficacy for both inhibitors, with similar levels of half-maximal inhibitory concentration (IC50) in FLT3-ITDMUT AML cells (17 nM and 14 nM in MOLM-13 and MV4;11 cells, respectively, for EC-70124; and 8 nM and 13 nM in MOLM-13 and MV4;11 cells, respectively, for midostaurin) (Figure 1a). This evidence concerns the gene FLT3 and acute myeloid leukemia.