In contrast to the prior study from Tran et al. (2020) which reports that MDM2 does not regulate c-Myc expression in neuroendocrine cancers [38], we found that manipulation of MDM2 expression level by siRNA or ectopic overexpression resulted in reciprocal changes in c-Myc expression level in MM cells. The gene discussed is MDM2; the disease is Miyoshi myopathy.