MYC and Miyoshi myopathy: To confirm that c-Myc binds to the MDM2 promoter in MM cells, we re-performed ChIP assay on four primary MM patient samples and two normal donor samples and found that c-Myc was enriched on the MDM2 promoter of MM patient samples but not normal donor samples, suggesting that c-Myc is involved in the upregulation of MDM2 in MM pathogenesis (Figure 6C).