In contrast, AKT3 and MDM4 amplifications were the only driver CNV events found in RAI-refractory PTCs (both in 4.5%, 3/66 of cases; p = 0.076; Fisher’s Exact Test), and only a single RAI-avid tumor (PTC-501) exhibited multiple driver CNV events (p = 1.000; Fisher’s Exact Test). This evidence concerns the gene MDM4 and neoplasm.