Regarding the infiltration of lymphocytes in TME, the circadian clock genes in clear cell renal carcinoma (ccRCC), including CLOCK, BMAL1, and CRY-1 have been positively correlated with a variety of immune cell infiltrates such as neutrophil cells, DCs, and CD4+ T cells [101]. The gene discussed is CLOCK; the disease is nonpapillary renal cell carcinoma.