CD274 and ovarian cancer: In ovarian cancer cells, IFN-γ has been proven to cause upregulation of PD-L1, which is responsible for disease progression, while inhibition of the IFN-γ 1 receptor may reduce PD-L1 expression in the mouse models of acute myeloid leukemia via extracellular signal-regulated MEK/kinase (ERK) and MYD-88/TRAF-6 pathways.