To highlight the clinical importance of TGF-β dysregulation, using the cBioPortal clinical database in our own analysis, we assessed the impact of genomic TGF-β alterations (alterations defined as TGF-β genomic mutations, structural variants and copy number variations; see Materials and Methods for the specific genes assessed) in relation to overall patient survival across 32 TCGA, PanCancer Atlas datasets which included 32 types of cancer and 10,953 patients [169,170]. Here, TGFB1 is linked to cancer.