CXCL8 and breast cancer: Importantly, when compared to other breast cancer subtypes, TNBC has been found to express increased levels of proinflammatory chemokines (CXCL1,2,3 and 8) compared to other breast cancer subtypes, highlighting the potential sensitivity of TNBC towards anti-TGF-β/IL6/IL8 targeted therapy, although more work is required to delineate the mechanisms and clinically relevant effects of this phenomena [195].