TGFB1 and dilated cardiomyopathy: To further highlight the importance of TGFB in cardiac function, using sequence-specific oligonucleotide probing (SSOP), Holweg et al. studied genomic DNA samples from heart transplant recipients and found that Leu > Pro (codon 10) polymorphism in the TGFB1 gene is associated with end-stage heart failure caused by dilated cardiomyopathy [72].