When the observed specific expression of EGR4-S in HER2+ cells is considered with higher EGR4-S protein levels in the HER2+ breast cancer cell lines (Figure 1), the data suggest the existence of a distinct mechanism of EGR4 regulation within HER2+ human mammary tumour cells that is not active in normal tissue or in tumour tissue of other breast cancer subtypes. This evidence concerns the gene ERBB2 and neoplasm.