Based on these collective findings, which demonstrate that the activation of the HER signalling pathway is associated with EGR4-S expression, that EGR4-S expression is also associated with cancer cell proliferation and drug responsiveness, and that EGR4-S expression is influenced by HSF1, we developed a schematic diagram to summarise the various interactions observed across our experimental results (Figure 7B). This evidence concerns the gene HSF1 and cancer.