While TGF-β signaling can affect multiple signaling pathways within the cell, human bladder cancer cells showed an ability of TGF-β to induce phosphorylation of AKT at Ser473, increase bladder cancer cell migration, and impact epithelial-to-mesenchymal transition (EMT) during cancer progression [105,112]. The gene discussed is TGFB1; the disease is urinary bladder carcinoma.