Over the past two decades, the major components of Notch signaling pathways, including Notch receptors 1 and 3 (NOTCH1 and NOTCH3); their ligands, such as jagged canonical Notch ligand 1 (JAG1) and delta like canonical Notch ligand 4 (DLL4); and downstream proteins, such as the Hes family bHLH transcription factor 1 (HES1) and DLG associated protein 5 (DLGAP5), have been intensively studied in ovarian cancers [20,21,22]. The gene discussed is HES1; the disease is ovarian carcinoma.