RUNX1 and acute myeloid leukemia: The chromosomal translocations of AML that have been linked to CDK6 addiction include t(8;21) generating RUNX1-RUNX1T1 (previously AML1-ETO), t(9;11) inducing KMT2A-MLLT3 (previously MLL-AF9) and t(5;11) leading to FLT3-ITD [5,6,7,8,9].