EPCAM and Lynch syndrome: In around 3 to 5% of CRCs, a defective MMR system, caused by germline mutations in the MMR genes MLH1, MSH2, MSH6, postmeiotic segregation increased 2 (PMS2), or in Epithelial Cell Adhesion Molecule (EPCAM) gene, is responsible for a hereditary disease called Lynch syndrome [12].