Conversely, neo-synthesis, commonly observed in more advanced stages of cancer, refers to a direct association between glycan alterations and the genetic mechanism for malignant transformation of cells, as seen in transcriptional induction of MGAT5 (GlcNAc transferase-V responsible for the synthesis of triantennary glycan) by v-src, H-ras, and v-fps genes [57]. This evidence concerns the gene HRAS and cancer.